4,4-DISUBSTITUTED-1,4-DIHYDROPYRIMIDINES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B农业专利-农业学术服务平台

发明人:: VANDYCK, KOEN,范迪科柯恩,范迪科柯恩,HACHE, GEERWIN YVONNE PAUL,哈契吉尔温,哈契吉爾溫,ROMBOUTS, GEERT,鲁伯兹吉尔特,魯伯茲吉爾特,VERSCHUEREN, WIM GASTON,范舒伦温,范舒倫溫,RABOISSON, PIERRE JEAN-MARIE,罗波森皮耶,羅波森皮耶

摘要：: Inhibitors of HBV replication of formula I including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein R1-R5, B and Z have the meaning as defined herein.The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.一種式I的HBV複製之抑制劑,包括其立體化學異構物形式、鹽、水合物及溶劑化物,其中R1-R5、B及Z具有根據本文定義之意義。本發明也關於製備該化合物之方法、含彼的醫藥組成物,及其單獨或結合其他HBV抑制劑在HBV醫療中的用途。