Leslie S. Johnson,Ling Huang,Nadine Tuaillon,Ezio Bonvini
申请号：
US15266421
公开号：
US10131713B2
申请日:
2016.09.15
申请国别(地区):
US
年份:
2018
代理人:
摘要：
This invention relates to antibodies that specifically bind HER2/neu, and particularly chimeric 4D5 antibodies to HER2/neu, which have reduced glycosylation as compared to known 4D5 antibodies. The invention also relates to methods of using the 4D5 antibodies and compositions comprising them in the diagnosis, prognosis and therapy of diseases such as cancer, autoimmune diseases, inflammatory disorders, and infectious disease.
