PROBLEM TO BE SOLVED: To provide a pharmaceutical composition for treating an ocular surface disease, which comprises histatin. SOLUTION: The first peptide and the second peptide are contained, the first peptide contains a first cyclized histatin, and the second peptide contains a second histatin, which causes the ocular surface disease. The method for treatment comprises the step of administering a therapeutic amount of the pharmaceutical composition to the surface of the eye. [Selection diagram] None【課題】ヒスタチンを含む、眼表面疾患を治療するための医薬組成物を提供する。【解決手段】第１のペプチドおよび第２のペプチドを含み、前記第１のペプチドは第１の環化したヒスタチンを含み、前記第２のペプチドは第２のヒスタチンを含み、前記眼表面疾患を治療するための方法は、治療上の量の医薬組成物を眼の表面に投与する工程を含む。【選択図】なし
