PYRUVATE DEHYROGENASE KINASES AS THERAEUTIC TARGETS FOR CANCER AND ISCHEMIC DISEASES

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专利权人:

发明人:

Chi V. Dang,Jung-whan Kim,Gregg L. Semenza

申请号：

US14514774

公开号：

US20150133524A1

申请日:

2014.10.15

申请国别(地区):

US

年份:

2015

代理人:

摘要：

The invention provides therapeutic and prophylactic compounds and methods for altering the activity of pyruvate dehydrogenase kinase (e.g. PDK1, PDK2, PDK3, PDK4). Such therapies are useful for the treatment of neoplasia. The invention further provides therapeutic and prophylactic compounds and methods of altering pyruvate dehydrogenase activity to treat or prevent cell death related to ischemia.

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中国工程科技知识中心

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http://www.ckcest.cn/home/