MODIFIED C-3 BETULINIC ACID DERIVATIVES AS HIV MATURATION INHIBITORS农业专利-农业专业知识服务系统

发明人:: REGUEIRO-REN, ALICIA,里圭洛蓝恩艾立西亚,里圭洛藍恩艾立西亞,SWIDORSKI, JACOB,史威朵斯基杰卡布,史威朵斯基傑卡布,LIU, ZHENG,刘正,劉正,SIT, SING-YUEN,席辛元,席辛元,CHEN, JIE,陈洁,陳潔,MEANWELL, NICHOLAS A.,明威尼可拉斯A,明威尼可拉斯A

摘要：: Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, modified C-3 betulinic acid and other structurally related natural prodructs derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors. These compounds are useful for the treatment of HIV and AIDS.本發明闡述具有藥物及生物作用性質的化合物、其醫藥組合物及使用方法。特定言之,提供具有獨特抗病毒活性之C-3經修飾樺木酸及結構上相關之其他天然產物衍生物作為HIV成熟抑制劑。此等化合物適用於治療HIV及AIDS。