pentaA two chain insulin analogue contains Aspartic Acid at position B10 and fluoro Phenylalanine at position B24 optionally Histidine or Glutamic Acid at position A8 optionally additional substitutions or modifications at positions A13 and/or A14 and/or B28 and/or B29. The analogue may be an analogue of a mammalian insulin such as human insulin may optionally include (i) N terminal deletion of one two or three residues from the B chain (ii) a mono peptide or dipeptide C terminal extension of the B chain containing at least one acidic residue and (iii) other modifications known in the art to enhance the stability of insulin. Formulations of the above analogues at successive strengths U 100 to U 1000 in soluble solutions at at least pH value in the range 7.0 8.0 in the absence or presence of zinc ions at a molar ratio of 0.00 0.10 zinc ions per insulin analogue monomer.
