The present invention relates to X-ray image data analysis of a part of a cardiovascular system of a patient in order to estimate a level of inflammation in the part of the cardiovascular system. X-ray image data is received, a segmented model of the part of the cardiovascular system is generated and predetermined features related to inflammation are extracted from the segmented model. The extracted features are used as input to an inflammation function for calculating inflammation values of which each represents a level of inflammation in the part of the cardiovascular system. The image data analysis can improve the estimation of inflammation. Furthermore, the inflammation values can be presented to a user together with suggestions for performing actions. This can for example enable a prediction of plaque development as well as future acute coronary syndrome events.
