DÉGRADATION DE LA PROTÉINE À MOTIF TRIPARTIE 24 (TRIM24) PAR CONJUGAISON D'INHIBITEURS DE TRIM24 AVEC UN LIGAND DE LA LIGASE E3 ET PROCÉDÉS D'UTILISATION

• 收藏
• 分享

专利权人:

Inc.;Dana Farber Cancer Institute

发明人:

BRADNER, James,BUCKLEY, Dennis,GECHIJIAN, Lara

申请号：

EP17816274

公开号：

EP3474899A4

申请日:

2017.06.23

申请国别(地区):

EP

年份:

2020

代理人:

摘要：

or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which act as protein degradation inducing moieties for tripartite motif-containing 24 (TRIM24). The present application also relates to methods for the targeted degradation of TRIM24 through the use of the bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to TRIM24 which can be utilized in the treatment of disorders modulated by TRIM24.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/