PROBLEM TO BE SOLVED: To provide lipid particles which have low cytotoxicity, can hold a nucleic acid molecule stably outside of cells (in blood), and can escape from an endosome to rapidly release the nucleic acid in cytoplasm, to provide a nucleic acid delivery carrier, to provide a composition for producing the nucleic acid delivery carrier, to provide a method for producing the lipid particles, and to provide a gene-introducing method.SOLUTION: Lipid particles contain, as components, a phospholipid having one or more amino groups and one or more nitrogen-containing heterocyclic groups, a neutral lipid having no nitrogen-containing heterocycle group, sterols, and a nucleic acid.COPYRIGHT: (C)2015,JPO&INPIT【課題】細胞毒性が低く、細胞外(血中)で核酸分子を安定に保持することができ、かつエンドソームから脱出して、速やかに細胞質中で核酸を放出できる脂質粒子、核酸送達キャリア、核酸送達キャリア製造用組成物、脂質粒子の製造方法及び遺伝子導入方法を提供すること。【解決手段】1以上のアミノ基と1以上の含窒素複素環基とを有するリン脂質、含窒素複素環基を含まない中性脂質、ステロール類、および核酸を構成成分として含む脂質粒子。【選択図】なし
