ATOMIC ENERGY COUNCIL-INSTITUTE OF NUCLEAR RESEARCH
发明人:
MA, KUO HSING,马国兴,馬國興,HUANG, WEN SHENG,黄文盛,黃文盛,CHEN, CHIA CHIEH,陈家杰,陳家杰,SHEN, LIE HANG,沈立汉,沈立漢
申请号：
TW099111774
公开号：
TWI520715B
申请日:
2010.04.15
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
This application examined the feasibility of simultaneous dopamine and serotonin transporter imaging using [123I]ADAM and [99mTc]TRODAT-1 single photon emission computed tomography (SPECT).Procedures: Simultaneous [123I]ADAM (185 MBq) and [99mTc]TRODAT-1 (740 MBq) SPECT was performed in three age-matched female Formosan rock monkeys. An asymmetric energy window was used for dual, and symmetric energy windows were used for single-isotope imaging. Oral fluoxetine (20 mg) and intravenous methylphenidate HCl (1 mg/kg) were given 24 h and 10 min, respectively, before dual-isotope SPECT to test imaging specificities of [123I] ADAM and [99mTc]TRODAT-1. Results: Comparable image quality and uptake ratios between dual- and single-isotope SPECT scans were found. Dual-isotope SPECT in fluoxetine-pretreated monkeys showed decreased uptake of [123I]-ADAM, but not of [99mTc]TRODAT-1. Dual-isotope SPECT in methylphenidate-pretreated monkeys showed decreased [99mTc]TRODAT-1 uptake without affecting [123I]-ADAM uptake. Conclusion: Simultaneous [123I]-ADAM and [99mTc]TRODAT-1 SPECT appears promising in nonhuman primates and may provide a suitable preclinical model with further clinical implications.一種雙同位素核醫造影方法,係用以評估雙同位素單光子放射電腦斷層攝影(Single Photon Emission Computed Tomography,SPECT)對靈長類腦中多巴胺及血清素系統變異情形之診斷效應者。藉此,達到可在一次檢查當中就能同時取得多巴胺及血清素兩系統之影像,不僅可節省兩次檢查之人力開銷及病人兩次往返醫院之花費,亦可大為減少臨床SPECT之利用率以降低成本。11...步驟(A)正常控制組藥物投予12...步驟(B)正常控制組影像擷取13...步驟(C)正常控制組影像資料分析14...步驟(D)藥物處理組藥物投予15...步驟(E)藥物處理組影像擷取16...步驟(F)藥物處理組影像資料分析
