The Brigham and Women's Hospital, Inc.;Tokitae LLC;Massachusetts Institute of Technology
发明人:
Shiyi Zhang,Andrew Bellinger,Carlo Giovanni Traverso,Robert S. Langer,Dean Liang Glettig,Lowell L. Wood, Jr.,Philip A. Eckhoff
申请号：
US15317601
公开号：
US10413507B2
申请日:
2015.06.11
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Enteric elastomers and related methods are generally provided. In some embodiments, the enteric elastomer is a polymer composite. Certain embodiments comprise a polymer composite in which hydrogen bonds within two carboxyl group-containing polymers cross-link the polymer networks into an elastic and pH-responsive polymer composite. Advantageously, this polymer composite has the capacity of being stable and elastic in an acidic environment such as that of the stomach but can be dissolved in a neutral pH environment such as that of the small and large intestines. In some embodiments, the polymer composites described herein comprise a mixture of two or more polymers with carboxyl functionality such that the two or more polymers form hydrogen bonds. In certain embodiments, the polymer composite has both enteric and elastic properties.
