PURPOSE: A multi porous bioactive spherical particle manufactured by using chitosan as a template is provided to be used in various fields such as a medicine transfer system or a reinforcement purpose of a biodegradable polymer, etc. as the particle has porosity. CONSTITUTION: A production method of a multi porous bioactive spherical particle includes the production of bioactive glass sol mixed with a chitosan solution and bioactive glass, and a process of making the bioactive glass sol into gel before treating with heat. The chitosan solution further includes acetic acid. The pH of the chitosan solution is 2-3. The bioactive glass includes a mixture of tetraethyl orthosilicate, triethylphosphate, and calcium nitrate. A mole fraction of a silicon oxide, a calcium oxide, and phosphorus pentoxide in the bioactive glass sol is 60:25:15 to 60:39:1. A gelation process is performed for 6-10 hours at a range of 50-70 deg. C. [Reference numerals] (AA) Chitosan particle treated to have positive potential； (BB) Coagulation of bioactive glass particle； (CC) Self assembly of chitosan-bioactive glass complex； (DD) Spherical micro particle with nano pores본 발명은 키토산 용액 및 생체활성유리를 혼합하여 생체활성유리 졸을 제조하고, 상기 생체활성유리 졸을 젤화 및 열처리하는 것을 포함하는 다공성 생체활성유리 구형입자의 제조방법에 관한 것이다.본 발명에 의해 제조된 생체활성유리 구형입자는 다공성을 가지므로, 약물 전달 시스템이나 생분해성 고분자의 보강용 등 다양한 영역에서 사용될 수 있다.
