Disclosed herein are novel uses of a compound of formula (I) as an inhibitor of bacterial two component signal transduction system (TCS), A–L–B–L–A (I) wherein, A is a moiety having a negative charge； L is –(C2H5–O)n–CH2– or a moiety consists of a carbocyclyl and a heterocyclyl respectively having 5 to 10 ring atoms and coupling together, in which n is 0 or 1； and B is a 5 to 10-membered carbocyclyl or heterocyclyl. The compound of formula (I) may suppress or inhibit the growth of bacteria, including the notorious multi-drug resistant bacteria.本揭示內容是關於一種式 (I) 化合物作為細菌雙分子訊息傳遞系統之抑制劑的新穎用途， A–L–B–L–A (I) 其中，A 是一具有負電荷的基團；L 是 –(C2H5–O)n–CH2–，或是一由碳環基及雜環基所組成的基團，其中該碳環基及雜環基分別具有 5 至 10 個環上的原子並相互耦接，其中 n 是 0 或 1；以及，B 是一 5 至 10 個原子的碳環基或雜環基。該式 (I) 化合物可用以抑制多重抗藥性細菌等細菌的生長。
