A Modular Upper Extremity Support System (MUESS) improves hand function by optimizing the balance of flexion and extension at the wrist and stabilizing thumb abduction. This is accomplished through a basic support unit of a forearm cuff, a wrist extensor strap, and a web spacer strap. Various components and inserts can be attached to the basic support unit. The MUESS has several interchangeable components, inserts, and attachments, which allow the hand therapist and other caregivers to make adjustments to the orthotic in real time to support various hand functions that are critical to activities of daily living such as grasping.