The present invention relates to an FGFR inhibitor with the structure of formula (I), its preparation method and application, and the definition of each substituent is as described in the specification and the scope of patent application. The series of compounds of the invention can be widely used to prepare drugs for treating tumors, cancer, myeloproliferative diseases, bone or chondrocyte disorders, and hypophosphatemia, and are expected to be developed into a new generation of FGFR inhibitor drugs.本發明涉及一種具有式(I)結構FGFR抑制劑、其製備方法和應用,各取代基的定義如說明書和申請專利範圍所述。本發明系列化合物可廣泛應用於製備治療腫瘤、癌症、骨髓增生性疾病、骨骼或軟骨細胞紊亂、低磷血症的藥物,有望開發成新一代FGFR抑制劑藥物。