TRWAŁA PRZECIWNOWOTWOROWA KOMPOZYCJA FARMACEUTYCZNA ZAWIERAJĄCA TEMOZOLOMID I SPOSÓB WYTWARZANIA KOMPOZYCJI

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专利权人:

Double Bond Pharmaceutical AB;Research Institute of Physical Chemical Problems of the Belarusian State University

发明人:

YURKSHTOVICH, MIKALAI,VEYEUNIK, DZMITRY,ALINOUSKAYA, VALIANTSINA,ATRAKHIMOVICH, NATALIA,HALOUCHYK, IRYNA,BELIAEV, SERGEY,YURKSHTOVICH, TATJANA,BYCHKOUSKI, PAVEL,FEDULAU, ALIAKSANDR,TRUKHACHOVA, TATSIA

申请号：

PL17725373

公开号：

PL3452017T3

申请日:

2017.04.28

申请国别(地区):

PL

年份:

2020

代理人:

摘要：

An anti-neoplastic stable pharmaceutical composition comprising Temozolomide, high substituted polysaccharide phosphate in salt form, and high substituted polysaccharide phosphate in acidic form, in particular in a weight ratio of from 5 to 20% Temozolomide to 30 to 80% of polysaccharide in salt form, the reminder up to 100% being polysaccharide in acidic form. The level of 5-aminomidazole-4-carboxamide is below 0.5% by weight of Temozolomide in both the composition and the formulation disclosed. Also disclosed is a hydrogel for intrathecal administration obtainable by contacting the composition with sterile water, a method of manufacture of the composition and uses of the composition and the gel.

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