Disclosed herein is a method of treating influenza A virus (IAV) infection by a fusion protein. According to some embodiments of the present disclosure, the fusion protein comprises a HBD peptide and a IgG1 Fc region. According to other embodiments of the present disclosure, the fusion protein comprises a DcR3 protein and a IgG1 Fc region. The present fusion protein is found to possess inhibitory effects on IAV-induced secretion of the inflammatory cytokine, and IAV-induced infiltration of inflammatory cell into the lung tissue. Accordingly, the fusion protein is useful for developing a medicament for the treatment or prophylaxis of IAV infection and/or ameliorating pulmonary injury caused by excessive inflammation associated with IAV infection in a subject.本揭示內容是關於一種利用一融合蛋白來治療A型流感病毒感染的方法。依據本揭示內容某些實施方式,該融合蛋白包含一HBD胜肽及一IgG1 Fc區域。依據本揭示內容其他實施方式,該融合蛋白包含一DcR3蛋白及一IgG1 Fc區域。本發明融合蛋白可抑制由A型流感病毒所引發之發炎細胞激素的分泌,以及由A型流感病毒所引發之發炎細胞浸潤至肺部組織。因此,本發明融合蛋白可用以研發一種藥物,以治療或預防一個體感染A型流感病毒及/或減緩該個體之肺部損傷,其中該肺部損傷主要是由與A型流感病毒感染相關之過量發炎反應所導致。
