RODEN, RICHARD, B.S.,KIRNBAUER, REINHARD,SCHELLENBACHER, CHRISTINA
申请号：
EP10762572
公开号：
EP2416798A4
申请日:
2010.04.12
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
This invention relates, e.g., to a virus-like particle (VLP) composition assembled from a chimeric polypeptide comprising a papilloma virus (e.g., human papillomavirus, or HPV) L1 major capsid protein, into which is inserted a surface-displayed peptide comprising a neutralizing epitope of a papillomavirus L2 protein. Vaccine compositions comprising the VLP are described, as well as methods for inducing an immune response (e.g., vaccinating) a subject against papilloma virus, using the VLP, and kits comprising the VLP, for carrying out a method of the invention.
