PROBLEM TO BE SOLVED: To provide a VEGF production promoter, an agent for improving the nature of hair, and an external preparation for a skin, which have a VEGF production promoting activity and can be used as a pharmaceutical product, a cosmetic or a food or a raw material for these products.SOLUTION: The VEGF production promoter, the agent for improving the nature of hair, or the external preparation for a skin contains, as an active ingredient, aculeoside A(spirosta-5,25(27)-diene-1&beta,3&beta,23&alpha,24&alpha-tetrol-1-O-[2,3,4-tri-O-acetyl-&alpha-L-rhamnopyranosyl-(1&rarr4)-&alpha-L-arabinopyranosyl]-24-O-6-deoxy-D-glycero-L-threo-4-hexulopyranoside) derived from plants of Ruscus in Liliaceae family.COPYRIGHT: (C)2012,JPO&INPIT【課題】血管内皮細胞増殖因子(VEGF)産生促進作用を有し、医薬品、化粧品若しくは食品、又はそれらの素材となり得る、VEGF産生促進剤、髪質改善剤、及び皮膚外用剤の提供。【解決手段】ユリ科ナギイカダ属植物由来のアクレオシドA(スピロスタ-5,25(27)-ジエン-1β、3β、23α、24α-テトロール-1-O‐[2,3,4‐トリ-O‐アセチル‐α‐L‐ラムノピラノシル‐(1→4)-α‐L‐アラビノピラノシル]‐24‐O-6-デオキシ-D-グリセロ-L-スレオ-4-ヘキスロピラノシド)を有効成分とするVEGF産生促進剤、髪質改善剤、皮膚外用剤。【選択図】なし
