#$%^&*AU2019250097A120191031.pdf#####Abstract Deuterated and non-deuterated forms of tetrahydrocurcumin are described herein. Methods of making tetrahydrocurcumin in deuterated and non-deuterated forms and pharmaceutical formulations including tetrahydrocurcumin in deuterated and nondeuterated forms are disclosed. Methods of treating a subject using deuterated forms of tetrahydrocurcumin or non-deuterated forms of tetrahydrocurcumin are also disclosed.