abstract disclosed are compositions and methods that provide pharmacodynamic effects specific to therapeutic macromolecules. the effects may result from reduced doses of therapeutic macromolecules in combination with immunosuppressant doses. the effects may also be enhanced with such compositions. translation of the summary patent summary of invention: "synthetic tolerogenic nanocarriers and therapeutic macromolecules for enhanced or reduced pharmacodynamic effects" the present invention relates to compositions and methods that provide specific pharmacodynamic effects for therapeutic macromolecules. the effects may result from reduced doses of therapeutic macromolecules in combination with doses of immunosuppressant. the effects can also be accentuated with such compositions. 1/1abstract disclosed are compositions and methods that provide pharmacodynamic effects specific to therapeutic macromolecules. the effects may result from reduced doses of therapeutic macromolecules in combination with immunosuppressant doses. the effects may also be enhanced with such compositions. tradução do resumo resumo patente de invenção: "nanocarreadores sintéticos tolerogênicos e macromoléculas terapêuticas para efeitos farmacodinâmicos acentuados ou reduzidos" a presente invenção refere-se a composições e métodos que fornecem efeitos farmacodinâmicos específicos para macromoléculas terapêuticas. os efeitos podem resultar de doses reduzidas de macromoléculas terapêuticas em combinação com doses de imunossupressor. os efeitos também podem ser acentuados com tais composições. 1/1
