A stapling device (100) for attaching a clip (205) to tissue is disclosed comprising a sheath (101) having a distal end (102) for delivery of said clip, a pusher unit (103, 103′) being movable inside said sheath along a longitudinal direction (104) of said sheath, said distal end comprising a clip guide (105, 105′) in which said clip is movable in said longitudinal direction, wherein said clip guide has a closed (G) configuration in which said clip guide is adapted to apply a restraining force on said clip so that said clip assumes a delivery shape (C), and an open (G′) configuration in which said clip assumes a relaxed shape (C′), wherein said pusher unit is movable from a proximal position (P) in which said clip guide is in said closed configuration, to a distal position (P′) in which said pusher unit engages said clip guide and the clip guide is in said open configuration. The clip guide comprises a first and a second clip guide arranged at radially opposite peripheries of the sheath and extending in the longitudinal direction.L'invention concerne un dispositif d'agrafage (100) pour fixer une pince (205) à un tissu, comprenant une gaine (101) ayant une extrémité distale (102) pour la pose de ladite pince, une unité de poussoir (103, 103') mobile à l'intérieur de ladite gaine le long d'une direction longitudinale (104) de ladite gaine, ladite extrémité distale comprenant un guide de pince (105, 105'), ladite pince étant mobile dans ladite direction longitudinale, ledit guide de pince ayant une configuration fermée (G) dans laquelle ledit guide de pince est conçu pour appliquer une force de retenue sur ladite pince de telle sorte que ladite pince adopte une forme de pose (C), et une configuration ouverte (G') dans laquelle ladite pince adopte une forme relâchée (C'), ladite unité de poussoir étant mobile d'une position proximale (P), dans laquelle ledit guide de pince est dans ladite configuration fermée, à une position distale (P') dans laquelle ladite unité de po
