Immunogenic compositions and a process for producing same

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专利权人:

发明人:

Heidi DRUMMER,Pantelis POUMBOURIOS

申请号：

US14776802

公开号：

US20160122395A1

申请日:

2014.03.17

申请国别(地区):

US

年份:

2016

代理人:

摘要：

The present invention provides a modified HIV envelope glycoprotein (Env) antigen or a lipid containing vehicle comprising same. The Env antigen comprises one of a second site suppressor mutation in residue 674 of the membrane proximal ectodomain region (MPER) of HIV gp41 a second site suppressor mutation which ablates a glycosylation site in the variable region (V1) region of gp120 or a second site suppressor mutation ablating a glycosylation site in the V1 region of gp120 and a second site suppressor mutation in residue 674 of the MPER of HIV gp41. It is preferred that the lipid containing vehicle is a HIVLP.

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