Yongdoo CHOI,Hyunjin Kim,Yun-Hee Kim,Daehong Kim,Inhoo Kim
申请号：
US13013193
公开号：
US20120045399A1
申请日:
2011.01.25
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Provided are a positively-charged superparamagnetic iron oxide nanoparticle (SPION), a contrast agent using the same, and a method of preparing the same. The positively-charged SPION includes a SPION, a polymer layer including a polymer containing many carboxyl groups coated on a surface of the SPION, and a cationic material coupled via an amide bond to a surface of the polymer layer. Therefore, the SPION may be prepared in a simple and reproducible process to have hydrophilicity and a strong positive charge. The prepared positively-charged SPION may have high uptake into a cell and stability, and be used in various applications as an effective contrast agent through non-invasive in vivo imaging.
