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Eluent Solution
专利权人:
ДжиИ Хелткер Лимитед (GB)
发明人:
ВИКСТРОМ Торильд (NO),СВАДБЕРГ Андерс (NO),ХЬЕЛЬСТУЕН Оле Кристиан (NO),ЭВЬЕ Даг М. (NO),ОКСЕНФЕЛЬД Лиане (NO)
申请号:
RU2013126979/15
公开号:
RU2013126979A
申请日:
2011.12.21
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A method for producing F for use in a radiofluorination reaction, comprising: (1) capturing an aqueous solution of F on an anion exchange column and (2) passing an eluent solution through said ion exchange column on which said F is adsorbed, to obtain an F eluent where said eluent solution contains a cationic counterion in a suitable a solvent wherein said suitable solvent contains alkanol, provided that said eluent solution does not contain acetonitrile. 2. The method of claim 1, wherein said anion exchange column is a QMA (Quaternary methylammonium) column. The method of claim 1, wherein said cationic counterion is a cryptand metal complex. The method of claim 3, wherein said metal of said cryptand metal complex is potassium. The method of claim 3, wherein said cryptand of said cryptand metal complex is cryptofix 222 (K222). 6. The method of claim 1, wherein said suitable solvent is an aqueous alkanol solution. The method of claim 6, wherein said alkanol is methanol. The method according to claim 1, comprising the additional step of: (3) drying said F eluted from said column in step (2). The method according to any one of claims 1 to 8, which is automated. The method according to claim 9, which is carried out in a cassette suitable for use with an automated radiochemical synthesis device. Radiofluorination reaction to obtain an F-labeled indicator for positron emission tomography (PET), wherein said radiofluorination reaction involves the interaction of a precursor compound with F, where said precursor compound can1. Способ полученияFдля применения в реакции радиофторирования, включающий:(1) захват водного раствораFна анионообменной колонке и(2) пропускание раствора элюента через указанную ионообменную колонку, на которой адсорбирован указанныйF, с получениемF-элюента, где указанный раствор элюента содержит катионный противоион в подходящем растворителе, где указанный подходящий растворитель содержит алканол, при условии, что указанный раствор элюента не содерж
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