#$%^&*AU2017258882A120181213.pdf#####230 ABSTRACT Provided herein are methods of eliciting an immune response to, and immunizing a mammal against, a tick neurotoxin, by administering to the 5 mammal one or more isolated tick neurotoxin proteins having an amino acid sequence of SEQ ID NOs: 2 to 7, 9 to 11 and 15 to 19. A related method of treating or preventing tick paralysis or infection, which includes administering one or more of the aforementioned isolated tick neurotoxin proteins or an antibody or antibody fragment that binds or is raised thereto is also provided. Also 10 provided is the aforementioned isolated tick neurotoxin proteins, an antibody or antibody fragment that binds or is raised thereto, a genetic construct that includes a nucleic acid sequence which encodes said isolated tick neurotoxin proteins, a host cell transformed with said nucleic acid sequence and a composition including same.
