FURANOCHALCONES EN TANT QU'INHIBITEURS DE CYP1A1, CYP1A2 ET CYP1B1 POUR LA CHIMIOPREVENTION DU CANCER

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专利权人:

DE MONTFORT UNIVERSITY;COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

发明人:

BHARATE, SANDIP BIBISHAN,SHARMA, RAJNI,JOSHI, PRASHANT,VISH-WAKARMA, RAM,CHAUDHURI, BHABATOSH

申请号：

CA3033569

公开号：

CA3033569A1

申请日:

2017.08.11

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

The present invention relates to the furanochalcone class of compounds of general formula A. The present invention particularly relates to the synthesis of furanochalcones and their CYP1A1, CYP1A2 and CYP1B1 inhibitory activity. In addition, the invention relates to the prevention or treatment of cancer caused by polyaromatic hydrocarbons (PAHs), 4-nitroquinoline-1-oxide, and N-nitroso-N- methylurea, heterocyclic amines, estrogen and 17ß-estradiol, resulting from the inhibition of CYP1A1, CYP1A2 and CYP1B1 enzymes.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/