Body support systems include central cores having one or more internal air flow guides that form part of each system for pressure redistribution, and withdrawal of heat and moisture away from an uppermost comfort layer or body-supporting layer(s). During operation of the system, heat and/or moisture is directed from the uppermost comfort layer or body-supporting layer(s) into the central core portion of the body support system and out of the body support system. The internal air flow guide(s) are formed of cellular polymer material and are coupled to the uppermost comfort layer to form an air flow path.