A protective sheath for protecting elongated medical devices positioned in, or through, the sheath while performing a surgical procedure. The sheath is formed of a thin, flexible material that provides and maintains a clean and sterile and reliable path for medical instruments to travel within. The device provides a barrier between a medical instrument, the orifice/opening in which the instrument enters the human body, and the path these instruments travel to other body organs or locations, and reduces unwanted translocation.