COMPOSITION PHARMACEUTIQUE COMPRENANT DES CELLULES SOUCHES DANS LESQUELLES EST SUREXPRIMÉ UN FACTEUR DE CROISSANCE DE L'ENDOTHÉLIUM VASCULAIRE EN TANT QUE PRINCIPE ACTIF DESTINÉE À PRÉVENIR OU À TRAITER UNE MALADIE NEURODÉGÉNÉRATIVE
Kyungpook National University Industry-Academic Cooperation Foundation
发明人:
申请号：
EP17747798.1
公开号：
EP3412296A1
申请日:
2017.02.03
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The present invention relates to a pharmaceutical composition containing stem cells in which vascular endothelial growth factor (VEGF) is overexpressed as an effective ingredient for preventing or treating neurodegenerative diseases. The stem cells in which VEGF is overexpressed according to the present invention effectively act against the neurodegenerative disease-induced VEGF reduction of neural stem cells in the SVC to inhibit the abnormal migration of neural stem cells, suppress inflammatory responses, and restrain the accumulation of cholesterol and spingolipids in the cerebral cortex, thus restoring the behavior exercise capacity of animal models, whereby the pharmaceutical composition can be used as an effective therapeutic agent for neurodegenerative diseases.
