International Business Machines Corporation;Agency For Science, Technology And Research
发明人:
Chin Willy,Coady Daniel J.,Engler Amanda C.,Hedrick James L.,Lee Ashlynn L. Z.,Ng Victor W. L.,Ong Zhan-Yuin,Yang Yi Yan
申请号：
US201313859037
公开号：
US9999633(B2)
申请日:
2013.04.09
申请国别(地区):
美国
年份:
2018
代理人:
Roberts Michael R.
摘要：
Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups. The end groups can comprise a covalently bound form of biologically active compound such as cholesterol. Other antimicrobial cationic polymers have a random copolycarbonate chain comprising a minor mole fraction of hydrophobic repeat units bearing a covalently bound form of a vitamin E and/or vitamin D2. The cationic polymers exhibit high activity and selectivity against Gram-negative and Gram-positive microbes and fungi.
