The system (SSE) has an impedance measurement block (BMI) for generating an electrical signal to be applied to a biological tissue (TB) to be stimulated and for measuring a biological response of the tissue to the electrical signal. A calculating unit (MC1) estimates a parameter of an electrical model of the tissue and its interface with the system. Another calculating unit (MC2) determines a parameter of a stimulation pulse to be applied to the tissue by the system. A signal generating block (BGS) generates the stimulation pulse to be applied to the tissue. Independent claims are also included for the following: (1) an integrated circuit for controlling the electrical stimulation system (2) a method for calibrating the electrical stimulation system.
