FORTIER, MICHEL,CHAPDELAINE, PIERRE,BRESSON, EVA,MADORE, ERIC
申请号：
EP08850869
公开号：
EP2220216A4
申请日:
2008.11.14
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
AKR1B1 (EC 1.1.1.21) is an aldose reductase that has mainly been associated with the polyol pathway, and more recently with lipid deperoxidation. We have discovered that the primary activity of this enzyme is rather a PGFS activity, catalyzing the transformation of PGH2 into PGF2&alpha；. AKR1B1 as a therapeutic target, and method for modulating its expression and activity are provided. Methods for regulating the expression and activity of PGF2&alpha； are also provided.
