STEVEN GERAINT WILLIAMS,JONATHAN GAWN,ALISTAIR SIMPSON IRVINE
申请号：
IN5724/DELNP/2007
公开号：
IN251015B
申请日:
2007.07.24
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
An isolated polynucleotide comprising (a) an element comprising at least 200 contiguous nucleotides of SEQ ID NO: 1, wherein said at least 200 contiguous nucleotides comprise from the immediate/early regulatory region of guinea pig CMV a promoter and/or an enhancer element and (b) an element comprising an expressible polynucleotide sequence characterised in that said isolated polynucleotide sequence comprises, in a 5 to 3 direction with respect to the sense strand of the expressible polynucleotide sequence, an enhancer, a single promoter, and said expressible polynucleotide sequence, and wherein said enhancer is operably-linked to said promoter, which is directly operably -linked to said expressible polynucleotide sequence and wherein said promoter is not naturally operably linked to said expressible polynucleotide sequence, wherein said polynucleotide sequence is capable of expressing a therapeutically useful polypeptide.
