Ana I. Jiménez,Ángela Sesto,Irene Gascón,José P. Román,Gonzalo González de Buitrago
申请号：
US12170116
公开号：
US08247387B2
申请日:
2008.07.09
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
