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COMPOSITION LIPOSOMALE ET PROCÉDÉ DE PRODUCTION ASSOCIÉ
专利权人:
Fujifilm Corporation
发明人:
申请号:
EP15786062.8
公开号:
EP3138557A1
申请日:
2015.04.30
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
Provided are a liposome composition which has a practically required long-term preservation stability, and which has a release rate of a drug on the order of several tens of hours due to releasability of a drug being able to be suitably controlled by rendering an inner water phase hyper-osmotic; and a method for producing the same. According to the present invention, it is possible to provide a liposome composition, including liposomes each of which has an inner water phase and an aqueous solution which constitutes an outer water phase and in which the liposomes are dispersed, in which each of the liposomes encapsulates a drug in a dissolved state, an osmotic pressure of the inner water phase is 2-fold to 8-fold relative to the osmotic pressure of the outer water phase, and a release rate of the drug from each of the liposomes is 10 %/24hr to 70 %/24hr in blood plasma at 37°C; and a method for producing the same.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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