The invention provides novel antibodies and methods for using recombinant antigen binding region specific to CD38 and antibodies and functional fragments containing the antigen binding region. CD38 plays an important role in various diseases or diseases.These methods take advantage of the newly discovered antibodies and the amazing properties of the antibodies, such as their ability to bind minipig derived CD38 and their ability to specifically kill cells expressing CD38 by cross-linking.These antibodies and new methods of using them can be used to treat hematological malignancies such as multiple myeloma.本發明提供了使用特異性針對CD38的重組抗原結合區和含有所述抗原結合區的抗體和功能性片段的新型抗體以及方法，CD38在各種病症或疾患中具有重要作用。這些方法利用了新發現的抗體和所述抗體驚人的性質，例如結合迷你豬來源CD38的能力和通過交聯誘導特異性殺傷表達CD38的細胞的能力。這些抗體以及使用這些抗體的新方法可用以治療例如血液惡性腫瘤，例如多發性骨髓瘤。
