ENDRES, Stefan,NIEDERFELLNER, Gerhard,SUSTMANN, Claudio,KLEIN, Christian,BOURQUIN, Carole,CASTOLDI, Raffaella,KOBOLD, Sebastian
申请号：
MX2014008963
公开号：
MX366965B
申请日:
2013.01.24
申请国别(地区):
MX
年份:
2019
代理人:
摘要：
The present invention relates to a bispecific (monoclonal) antibody molecule with a first binding domain binding an antigen on CD8+ T-cells that does not naturally occur in and/or on CD8+ T-cells and a second binding domain binding to a tumor specific antigen naturally occurring on the surface of a tumor cell. The bispecific (monoclonal) antibody molecules are particularly useful in combination with transduced CD8+ T-cells comprising an antigen which does not naturally occur in and/or on CD8+ T-cells and/or a T-cell receptor. The invention provides the use of said (bispecific) antibody molecules as a medicament, the (bispecific) antibody molecules for use in a method for the treatment of particular diseases as well as a pharmaceutical composition/medicament comprising said (bispecific) antibody molecules, wherein said (bispecific) antibody molecules are to be administered in combination with transduced CD8+ T-cells comprising an antigen which does not naturally occur in and/or on CD8+ T-cells and/or a T-cell receptor in a specific treatment regimen. Further aspects of the invention are nucleic acid sequences encoding said bispecific (monoclonal) antibody molecules, vectors.host cells, methods for the production of the (bispecific) antibody molecule as well as a kit comprising the (bispecific) antibody molecule of the invention.La presente invención se refiere a una molécula de anticuerpo biespecífico (monoclonal) con un primer dominio de unión que se enlaza a un antígeno sobre células T CD8+ que no se presenta naturalmente en y/o sobre las células T CD8+ y un segundo dominio de unión que se enlaza a un antígeno específico de tumor que se presenta naturalmente sobre la superficie de una célula tumoral. Las moléculas de anticuerpos biespecíficos (monoclonal) son particularmente útiles en combinación con células T CD8+ transducidas que comprenden un antígeno que no se presenta naturalmente en y/o sobre las células T CD8+ y/o un receptor de célula T. La invención propor
