Methods for producing viloxazine salts and novel polymorphs thereof

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专利权人:

Supernus Pharmaceuticals Inc.

发明人:

Liang, Likan,Bhatt, Padmanabh P.,Dain, David,Taquet, Jean-Philippe,Pechenov, Aleksandr,Tchesnokov, Alexei,Mariaux, Reynold

申请号：

AU2011240773

公开号：

AU2011240773A1

申请日:

2011.04.12

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

Provided here are methods of manufacture of viloxazine and its various salts, as well as viloxazine-related compounds, such as novel intermediate reaction products and polymorphs thereof. In particular, the methods provide a substantially pure API of viloxazine HC1 while avoiding undesirable impurities. The methods further provide for separating, identifying, and characterizing novel polymorphs of viloxazine. Further provided are methods for synthesis and identification and characterization of novel intermediates of viloxazine, as well as for some important metabolites and precursors of metabolites of viloxazine.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/