Fluorene compounds (I), their tautomers, racemic isomers, enantiomers and diastereomers, mineral/organic acid/base addition salts are new. Fluorene compounds of formula (I), their tautomers, racemic isomers, enantiomers and diastereomers, mineral/organic acid/base addition salts are new. Het : 5-11 membered aromatic or partially unsaturated dihydro or tetrahydro mono or bicyclic heterocycle containing 1-4 heteroatoms of N, O or S (optionally substituted by R)； R : H, halo, CF 3, nitro, cyano, alkyl, OH, SH, amino, (di)alkylamino, alkoxy, alkylthio, carboxy (optionally esterified by alkyl), carboxamide, CO-NH(alkyl), CO-N(alkyl) 2, NH-CO-alky, NH-SO 2-alkyl or optionally substituted heterocycloalkyl； R1 : X-(A-B1) n-CONH 2, X-(A-B) n-OCONH 2, X-(A-B1) n-NH-CONH 2, X-(CH 2) m-heterocycloalkyl, X-(CH 2) m-aryl or X-(CH 2) m-heteroaryl； X : -O-C(O), -NH-C(O), NH-CS, -NHCO-CH 2-O-, -NH-CO-CH 2-S-CH 2-CO-NH-, -NH-CO-(CH 2) 2-SO 2- or -NH-CO-CH 2-N(CH 3)-CO-； A, B1 : a bond, CH 2, CH-alkyl or CH-aralkyl； n : 1-2； m : 0-1； R2, R2a : H, halo, CF 3, nitro, cyano, alkyl, OH, SH, amino, (di)alkylamino, alkoxy, alkylthio (methylthio), carboxy (optionally esterified by alkyl), carboxamide, CO-NH(alkyl) or NH-CO-(alkyl) (all the alkyl, alkoxy and alkylthio are optionally substituted)； p : 1-4； q : 1-3； and L : a bond, CH 2, C(O), O, S or NH. An independent claim is included for compositions comprising (I). [Image] ACTIVITY : Cytostatic； Neuroprotective； Anticonvulsant； Nootropic； Antiparkinsonian； Nephrotropic； Antimalarial； Protozoacide； Fungicide； Antiinflammatory； Hepatotropic； Virucide； Muscular-Gen； Anticoagulant； Thrombolytic； Antipsoriatic； Uropathic. MECHANISM OF ACTION : Heat shock protein-90 (HSP90) inhibitor. The ability of (I) to inhibit heat shock protein was tested by inhibiting ATPasic activity. The results showed that 1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid [4-(1H-indol-2-yl)-9H-fluoren-9-(R,S)-yl]-amide exhibited an IC 5 0 value of less than 1 mu M.
