This invention relates to a device (10) for taking at least one sample of soft tissue from an organ, said device comprising a body (11) and a needle (12) arranged in the body and extending at least partly outside the body through the front end of the body, the needle is formed by a stylet and a cannula coaxial with said stylet. The device comprises a mechanism for arming the needle, designed for sequentially moving the stylet and then the cannula from a rest position to a shooting position wherein the stylet and the cannula are retracted towards the rear end of the body, and a triggering mechanism designed to release the stylet then the cannula and to allow their displacement from the shooting position to the rest position. The cannula is coupled to a cannula slider (24) comprising at least one retaining element (26) for maintaining the cannula slider in a shooting position. The stylet is coupled to a stylet slider (30) comprising at least one retaining element (32) for maintaining the stylet slider in a shooting position and means for unlocking the cannula slider. This device is characterized in that the stylet slider (30) comprises a support device (41) integral with the stylet and a guide device (42) mobile in the body (11) of the device, in that the displacement of the guide device (42) leads to the displacement of the support device (41) and in that the support device (41) and the guide device (42) have a clearance between each other.
