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Compositions and Methods for Treating Myotonic Dystrophy Type 1
专利权人:
Lucio Comai;Sita REDDY;Nouri Neamati
发明人:
Sita REDDY,Lucio Comai,Nouri Neamati
申请号:
US13587858
公开号:
US20140051709A1
申请日:
2012.08.16
申请国别(地区):
US
年份:
2014
代理人:
摘要:
Disclosed is a compound for treatment of Myotonic Dystrophy type 1 having the formula:Wherein X is selected from the group consisting of O, N, C, or S, Y is a homo- or heteroatomic 5-membered ring comprising one or more atoms selected from the group consisting of N, O, S, and C, Z is an optionally substituted aryl group or optionally substituted heteroaryl, including but not limited to halogenated benzenes, pyridines, substituted benzene, substituted pyridine, R2=hydroxy, acyl, alkoxyl, esters, ethers, cyclic ethers, and lactones, R3=H, alkyl, an optionally substituted alkyl, aliphatic ether, ester, cyclic unsaturated and aromatic ring groups, and R1, R4 and R5 are independently selected from the group consisting of hydrogen, halogen, alkyl, and alkoxyl or a pharmaceutically or cosmetically acceptable salt, solvate, or hydrate thereof.
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