A VITAL SIGN MEASUREMENT DEVICE INCLUDES A SENSOR FIXATION DEVICE (102), A SENSOR FRAME (200) HELD BY THE SENSOR FIXATION DEVICE (102), AN OPTICAL SENSING SYSTEM (104) HELD BY THE SENSOR FRAME (200), AND AN OUTPUT UNIT (106). THE SENSOR FIXATION DEVICE (102) IS ADAPTED TO BE PLACED AGAINST AN ANATOMICAL LOCATION OF A SUBJECT, WITHIN WHICH IS AN ARTERY (118). THE OPTICAL SENSING SYSTEM (104) INCLUDES AN OPTICAL WAVEGUIDE (212), AN OPTICAL SOURCE DEVICE (202) TO SUPPLY OPTICAL ENERGY TO THE OPTICAL WAVEGUIDE (212), AND AN OPTICAL DETECTOR (240) TO DETECT AN AMOUNT OF OPTICAL ENERGY EXITING THE OPTICAL WAVEGUIDE (212). THE OPTICAL SENSING SYSTEM (104) IS ADAPTED TO SENSE AN ARTERIAL PULSE FROM THE COMPRESSION OR FLEXING OF AT LEAST A PORTION OF THE OPTICAL WAVEGUIDE (212) RESULTING IN REDUCTION OF THE AMOUNT OF LIGHT EXITING THE OPTICAL WAVEGUIDE (212). THE OUTPUT UNIT (106) IS CONFIGURED TO RECEIVE A SIGNAL INDICATIVE OF THE AMOUNT OF LIGHT EXITING THE OPTICAL WAVEGUIDE (212) AND TO GENERATE A MEASURE OF THE VITAL SIGN BASED AT LEAST IN PART ON THE RECEIVED SIGNAL.
