The present disclosure is generally directed to a resettable drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The drug delivery device comprises a housing, a cartridge holder releasably attached to the distal end of the housing, a piston rod engaging a housing insert and a drive member, a dose setting member guided within the housing to allow rotation of the dose setting member during dose setting and dose dispensing, a clutch for rotationally coupling the drive member and the dose setting member, and a locking element which is rotationally constrained to the housing and is axially movable relative to the housing between a proximal dose setting position and a distal resetting position.
