Blood purification apparatus (100, 200), the blood inlet path for allowing flow into the extracted blood from the patient to the dialysis unit (105, 205) and (103, 203), said dialysis unit the blood back to the patient (105, 205 blood outflow channel for causing the outflow from) (103, 203) and an extracorporeal blood circuit having a (102, 202) with is, the dialysis unit (105, 205) dialysate inflow channel (107, 207) and It has a dialysis drainage outflow tract (108 and 208). The aforementioned blood purification apparatus, the acid-base balance of the blood is characterized by a control loop for the loop control, bicarbonate by bicarbonate solution is supplied to the blood, at least one measuring means for measuring a blood buffer parameters (124,124a, 224,224a), the control is associated with the loop, the blood buffer parameters are selected from the group consisting of bicarbonate concentration and CO 2 partial pressure, measured in the blood buffer parameters signal corresponding to the actual value may be supplied to the loop controller (125, 225), said control device, by the supply of bicarbonate, the actual value of said blood parameter buffer, predeterminable desired value or it will be adjusted to the desired range. The aforementioned blood purification device, at least one pH measuring means (150a, 250a) further characterized by, the pH measuring means, disposed upstream of the dialysis unit in the extracorporeal blood circuit (102, 202) (105, 205) and being is, signals corresponding to the pH value may be supplied to the alarm device (130, 230), said alarm device, when it is below or exceeds a predeterminable pH value or pH value range, a warning It wants to send a signal. .BACKGROUND血液浄化装置(100、200)は、患者から取り出した血液を透析ユニット(105、205)へ流入させるための血液流入路(103、203)と、患者へ戻す血液を前記透析ユニット(105、205)から流出させるための血液流出路(103、203)とを具備する体外血液回路を(102、202)備えており、前記透析ユニット(105、205)は透析液流入路(107、207)および透析排液流出路(108、208)を備えている。上記血液浄化装置は、血液の酸塩基バランスをループ制御するための制御ループを特徴とし、重炭酸塩水溶液によって重炭酸塩が血液へ供給され、血液緩
