Jordan J. Green,Joel C. Sunshine,Nupura S. Bhise,Ron B. Shmueli,Stephany Y. Tzeng
申请号：
US15821368
公开号：
US20180177881A1
申请日:
2017.11.22
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure provides significant changes to efficacy in a cell-type dependent manner. Polymers presented here are more effective than commercially available materials, such as LIPOFECTAMINE 2000™, FUGENE®, or polyethylenimine (PEI), for gene delivery to cancerous fibroblasts or human primary fibroblasts. The presently disclosed materials may be useful for cancer therapeutics and regenerative medicine.
