COMPOSITIONS ET PROCEDES POUR LE TRAITEMENT DU CANCER AVEC IMMUNOTHERAPIE ANTI-CD33

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专利权人:

LENTIGEN TECHNOLOGY, INC.;THE U.S.A., AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND MAN SERVICES

发明人:

DIMITROV, DIMITER S.,ORENTAS, RIMAS,SCHNEIDER, DINA,DROPULIC, BORO,ZHU, ZHONGYU

申请号：

CA3057838

公开号：

CA3057838A1

申请日:

2018.03.23

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

The present disclosure relates to chimeric antigen receptors (CAR) containing CD33 antigen binding domains, including nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed. Experimental results are provided for 7 different CD33 external domains coupled a transmembrane domain derived from the human CD8 protein, a 4-IBB costimulatory domain and a CD3 zeta signalling domain

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http://www.ckcest.cn/home/