КЭМПБЕЛЛ Уилльям Р. (US),ПОЛСЕН Нил Э. (US),ДЖОНСОН Роланд Х. (US),ХЭПЛЕР Дуглас И. (US)
申请号：
RU2012124067/15
公开号：
RU2012124067A
申请日:
2010.11.10
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A method of treating or preventing an infectious disease of otitis externa and its complications by topical administration of a pharmaceutically acceptable composition into the external auditory canal, wherein said composition does not include cellulose viscosity-enhancing or adhesive compounds and is not in gel form, and wherein said composition comprises a lipid carrier and at least two active agents selected from the group consisting of antibiotics, antifungal agents, antiparasitic agents, antiviral agents, non-steroidal anti-inflammatory drugs (NSAID), analgesics, anesthetics and steroids, which comprises introducing the composition into the ear canal in a single dose sufficient to ameliorate a clinical or eliminate disease.2 undergoing treatment. The method of claim 1, wherein the lipid carrier is a lipid vesicle. The method of claim 1, wherein the one active agent in said composition is an antibiotic. The method of claim 1, wherein the one active agent in said composition is an antifungal agent. The method of claim 1, wherein the one active agent in said composition is a non-steroidal anti-inflammatory agent (NSAID). The method according to claim 3, wherein the antibiotic is selected from the group consisting of quinolone antibiotics, penicillin antibiotics, macrolide antibiotics, cephalosporin antibiotics, sulfa antibiotics and beta-lactamase inhibitors. The method of claim 6, wherein said antibiotic comprises thiamphenicol. The method according to claim 4, wherein said antifungal agent is an antifungal avg1. Способ лечения или предупреждения инфекционного заболевания наружного отита и его осложнения посредством местного назначения фармацевтически приемлемой композиции в наружный слуховой проход, причем указанная композиция не включает увеличивающие вязкость целлюлозы или адгезионные соединения и не находится в форме геля, и причем, указанная композиция включает липидный носитель и, по крайней мере, два активных агента, выбираемых из группы, состоящей из а
