Provided are methods of determining the quantity and location of &bgr；III-tubulin expression in a subject, which may be used to determine the location and/or extent of excessive or uncontrolled growth of cells such as tumors. Such methods may include administering at least one compound to a patient and determining the quantity and location of &bgr；III tubulin expression within the patient by visualizing the compound within the patient. Visualization of the compound may be indicative of the binding of the compound to cells that are actively expressing &bgr；III tubulin.본 발명은 암 및 혈관형성을 억제하는 탈리도마이드의 유사체 및 유도체를 제공한다. 또한, 본 발명은 미세관 중합을 파괴시키는 화합물을 제공한다. 본 발명은 돌연변이 p53을 포함하는 암의 치료 방법을 제공한다.
