Michael McMillian;Daniel T. Laskowitz;William D. Matthew
发明人:
Daniel T. Laskowitz,William D. Matthew,Michael McMillian
申请号：
US12328625
公开号：
US08093209B2
申请日:
2008.12.04
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Methods of suppressing the activation of microglial cells in the Central Nervous System (CNS), methods of ameliorating or treating the neurological effects of cerebral ischemia or cerebral inflammation, and methods of combating specific diseases that affect the CNS by administering a compound that binds to microglial receptors and prevents or reduces microglial activation are described. ApoE receptor binding peptides that may be used in the methods of the invention are also described, as are methods of using such peptides to treat peripheral inflammatory conditions such as sepsis. Also described are methods of screening compounds for the ability to suppress or reduce microglial activation.
